Targeted therapies are not typical chemotherapy drugs. They work by interfering with the action of specific molecules in the cancer cell. Ibrance is the first available drug to target molecules called CDK 4 and CDK 6, which work with estrogen and progesterone receptors to stimulate the growth of breast cancer cells. It is also called a kinase inhibitor. Inhibiting these molecules slows tumor growth. Ibrance is available by prescription in capsule and tablet forms....

Inter have denied any contact with Madrid over a possible deal for Icardi, who has hit 16 goals in 15 league games to fire Luciano Spalletti’s team to the top of Serie A. Madrid have been struggling in front of goal this season, having allowed Alvaro Morata to join Chelsea, while Cristiano Ronaldo has only hit the net twice in La Liga. Karim Benzema, meanwhile, has faced criticism over his form and was embroiled in a spat with Gary Lineker regarding his performances, although Kovacic defended the striker despite appearing to tout Icardi for a move to Madrid....

“An ICE agent posing as a homeless women (sic) tried to access our shelter last night to look for a family, disregarding the fact that we are considered a Sensitive Location,” the tweet, which was shared by ICE, said. " Not only are we are religious organization, the shelter is located in a church," the Twitter user wrote. The tweet appeared to accuse at least one ICE agent of attempting to enter the Redmond United Methodist Church the day before under the guise of requiring shelter....

Earlier this week, a Tigard-Tualatin School District official told The Portland Tribune that, from the school board’s understanding, Tomas Galvan-Rodriguez had been arrested at a bus stop after walking his two children there last week. “Two of our students…their [parent] walked them to the school bus, the kids got on the school bus and ICE came and arrested the parent,” Jill Zurschmeide, school board director, told the outlet on Monday....

In the Netflix series, which was produced by Selena Gomez and looks at the real-life impacts of the Trump administration’s hardline immigration policies, immigration lawyer Andrea Martinez can be seen trying to accompany her client, a 3-year-old child from Honduras, to be reunited with his mother at an ICE office in Kansas City before the pair’s scheduled deportation. An ICE agent appears to allow Martinez to follow her client until the moment they reach the front door of the building....

The tweet, posted on Sunday, shows the frontline worker who goes by the username @kathryniveyy, looking young and healthy compared to a recent photo of her with tired eyes, mask lines and bruises, plus the expression of someone who has been working tirelessly for months. Her post, which reads “How it started – How it’s going,” referencing the photos, has garnered 250,000 likes and counting. The post has been flooded with thousands of messages of gratitude and numerous comments from medial professionals experiencing similar ordeals....

A partial loss of a generator at Thibodaux Regional Health System in Lafourche Parish sent doctors at the hospital scrambling to keep COVID patients breathing as they moved them to a different floor in the hospital. The Louisiana Department of Health told Nola.com that patients were being bagged by hand on Sunday after the generator failure, meaning that ICU staff had to manually pump air in and out of their lungs in place of ventilators that were keeping them alive....

The running back from Spokane, Wash., signed with Vandals in 2015 but never got an opportunity to play in order to battle the disease. MORE: Ranking top college football states | Early Heisman field Malek served as a scholarship student assistant while undergoing treatment, which included having his right leg amputated last summer. He represented the Vandals as a team captain for last season’s opener against Ohio. “I am thankful Jace Malek was part of our team,” coach Paul Petrino said in a statement Sunday....

These all belong to a family of devices on the drawing board at places like IBM, Xerox’s Palo Alto Research Center (PARC) and the Media Lab at the Massachusetts Institute for Technology. Some are in advanced stages of prototyping. They include such things as microchips farmers till into the soil to measure moisture and acidity; building materials that adjust resistance to wind and earthquake; insulation that changes according to weather conditions....

The loss of Ginsburg, who graduated from Columbia Law School, left only graduates from Harvard and Yale on the Supreme Court. Trump vowed to nominate a woman to fill Ginsburg’s spot and 10 of the 12 women on his publicly released list didn’t graduate from Harvard or Yale, including Circuit Judges Amy Coney Barrett and Barbara Lagoa, two of his reported top contenders. Only two women on Trump’s original list, White House counsel Kate Todd and District Court Judge Sara Pitlyk, graduated from Harvard or Yale....

And even more change. MORE: Crazy 2015 coaching carousel | Does Bama’s opponent matter? If you think this coming offseason of coaching uncertainty already is full tilt, wait and see what happens if LSU athletic director Joe Alleva does the unthinkable and fires arguably the most successful coach in school history. If LSU decides to part with one of the game’s best coaches — and agrees to doll out $17 million in buyout money ($15 million for Miles; $2 million for his assistants) — those making that decision better have an elite coach they know will accept the job....

In a survey of 1,187 people in the U.S., carried out by YouGov on behalf of the Wellcome Trust, respondents were found to support international collaboration of treatments and vaccinations against COVID-19. The poll found 83 percent of Americans think governments should work together to make sure drugs to stop the virus are manufactured by as many countries as possible and distributed across the world to everyone in need....

We know you are busy trying to go 1-0 this week, but the college football world is not going to let you focus solely on Penn State beating Illinois. Sure, you have a top-10 team, you’re in the thick of the Big Ten East race and there is a realistic path to the College Football Playoff should quarterback Sean Clifford come back healthy. But you know how things work nowadays....

Against Michigan State on Saturday, Ekpre-Olomu grabbed an interception off of MSU QB Connor Cook that was absolutely inhuman. That’s the kind of turnover-reliant defense the Ducks run, and Ekpre-Olomu is an absolute nightmare for opposing quarterbacks. By this point in the game, it felt like this was the Ducks kicking ol’ Sparty down into a big, bottomless pit. (h/t and photo credit to SB Nation)

If he’s not losing 65 games as a reserve for the Lakers or getting dry-snitched on by rookies, he’s saying stupid stuff about his fiancee for the world to see. MORE: What Swaggy would do as Lakers coach Which brings us to Wednesday. Young’s on-again, off-again (who really cares at this point?) significant other, rapper Iggy Azalea, recently made headlines, not for selling records of course, but because she said something derogatory about someone who actually does....

After rescuing a point for Chen Jingang’s men in their last game prior to the international break, the 28-year-old missed a chance to nick the curtain raiser for the Changchun outfit. The forward failed to convert a penalty in the 12th minute which could have lifted the home team as they ended up with a goalless first half with their visitors. However, on resumption from the break, Xiaofei Zhang eventually broke the deadlock in the 61st minute and ten minutes later, Eran Zahavi levelled proceedings....

Two of the best goaltenders in the game — Igor Shesterkin of the Rangers and Andrei Vasilevskiy of the Lightning — will square off beginning Wednesday in Game 1. On one side, there is the 26-year-old Shesterkin, who in a few weeks will very likely be handed the Vezina Trophy. He was sensational this season as the backbone for a New York team that relied heavily on him to win games....

The forward last scored in the English topflight on December 26, 2016 after replacing Nolito in Manchester City’s 3-0 victory over Hull City at the KCOM Stadium. Little did Iheanacho realize that his goal against the Tigers would be the last he’d get in the Premier League until netting against West Bromwich Albion on Saturday at the Hawthorns. A run of 33 league games had passed, with Iheanacho making a stop at King Power Stadium along the way....

Omar and the other members of the so-called Squad of progressive Democrats have been routinely attacked by the president and other Republicans. Democrats in the House of Representatives, joined by four Republicans, formally condemned Trump in July 2019 after he shared a series of racist tweets telling the four progressive representatives—all of whom are women of color—that they should “go back” to where they came from. But this did not deter Trump from repeatedly attacking Omar and the others....

“You may shoot me with your words, You may cut me with your eyes, You may kill me with your hatefulness, But still, like air, I’ll rise - Maya Angelou,” the 37-year-old Minnesota Democrat tweeted. The president dedicated a considerable portion of his campaign rally speech in Greenville, North Carolina earlier this evening attacking the four progressive lawmakers — Reps. Alexandria Ocasio Cortez, Ilhan Omar, Ayanna Pressley and Rashida Tlaib — all women of color, whom he told to “go back and help fix the totally broken and crime infested places from which they came” in a series of tweets over the weekend....